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metronidazole will improve the level or effect of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.bosentan will reduce the level or influence of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.diazepam will boost the stage or outcome of tazemetostat by influencing hepatic/i